Mechanisms of Hepatic Very Low Density Lipoprotein Overproduction in Insulin Resistance
نویسندگان
چکیده
منابع مشابه
Insulin, diabetes and hepatic very-low-density lipoprotein metabolism.
29. Cannon, B. & Nedergaard, J . (1985) Essays Biochem. 20, 110-164 30. Seydoux, J., Chivet, A., Schneider-Picard, G., Bas, S., Mesch, E., Assirnacopoulos-Jeannet, F., Giacobino, J. P. & Girardier, L. ( 1983) Endocrinology (Baltimore) 1 13,604-6 10 31. Rothwell, N. J . & Stock, M. J. (1981) Metab. Clin. Exp. 30, 673-678 Received 3 August 1988 32. Rothwell, N. J., Saville, M. E. & Stock, M. J. (...
متن کاملSynthesis and function of hepatic very-low-density lipoprotein.
Most of the triacylglycerol (TAG) utilized for the assembly of very-low-density lipoprotein (VLDL) in the secretory apparatus of the hepatocyte is mobilized by lipolysis of the cytosolic TAG pool, followed by re-esterification. The lipases involved include arylacetamide deacetylase and/or triacylglycerol hydrolase. Some of the re-esterified products of lipolysis gain access to an apolipoprotein...
متن کاملTargeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.
Loss of ABCA1 activity in Tangier disease (TD) is associated with abnormal apoB lipoprotein (Lp) metabolism in addition to the complete absence of high density lipoprotein (HDL). We used hepatocyte-specific ABCA1 knock-out (HSKO) mice to test the hypothesis that hepatic ABCA1 plays dual roles in regulating Lp metabolism and nascent HDL formation. HSKO mice recapitulated the TD lipid phenotype w...
متن کاملAssembly and secretion of hepatic very-low-density lipoprotein.
In contrast to water-soluble fuels such as glucose or ketone bodies, the use of lipids as an energy source for tissues has required the development of complex structures for their transport through the aqueous plasma. In the case of endogenously synthesized triacylglycerol this is achieved by the assembly and secretion of hepatic VLDL which provides the necessary stability in an aqueous medium....
متن کاملThe enzymology of hepatic very-low-density lipoprotein assembly.
The synthesis and export of triacylglycerol (TAG) by the liver provides mammals with an efficient means of transporting a powerful source of energy either for storage in adipose tissue or for utilization, predominantly by muscle tissue. On a molar basis, the transport of large quantities of energy as TAG may be achieved at relatively low concentrations of TAG in the blood plasma. Similar amount...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.275.12.8416